Chronic Insomnia is a significant public health problem of modern lifestyle, reflected by the high prevalence of this pathology worldwide. Homeopathy gives us the possibility to successfully treat people struggling with this pathology, thanks to individualization and holistic approach. I will illustrate this through a case example of a 45-year-old man, treated for years in psychiatry, also including psychotherapy, helped finally by the individualized homeopathic remedy. The key for finding the right remedy was a deeper understanding of the person in the disease, the analysis of the case according to Synergy approach, finding the exact rubrics and Materia Medica references. The long-term follow-up of the patient testifies to the effectiveness of the treatment.