As complex chronic illness is on the rise worldwide, homeopathy presents a unique opportunity for restoration of health, even where other modalities have failed. But it is rare that someone comes to homeopathy without having tried other therapies, or potentially using them simultaneously. The use of non-homeopathic therapeutics often further complicates already complex chronic disease. In this lecture we will explore what Hahnemann says about the nature of complex chronic disease, the use of multiple therapies and what insights they can give us to the attunement of the vital force. We will also discuss the practicalities of safely and effectively working with people using multiple therapies, how to manage the homeopathic case with their presence, and how to safely transition off them when indicated.